The sensitivity analysis of thermal parameters in the homogeneous human brain model is presented, investigating their influence on thermal rise, as a direct consequence of the high frequency exposure. The novelty presented is the combination of modern Stochastic Collocation method with the thermal part of the existing deterministic electromagnetic-thermal model. The sensitivity analysis excludes the less important parameters and can be used as a prior step of more complex experimental or computational models. In addition, obtained confidence margins give more precise estimate if temperature elevation reaches the prescribed limits or not.